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We compared prednisolone(PRED)and azathioprine(AZA)versus prednisolone alone in the treatment of MG.Prednisolone alone or combined with azathioprine is widely used in the treatment of MG,but no randomized placebo-controlled comparative trial data are available.The prednisolone dose and clinical outcome were compared in a multicenter randomized double-blind study of 34 MG patients who were followed up for 3 years. Incidence of side effects was less in the PRED+AZA group.Azathioprine as an adjunct to alternate day prednisolone in the treatment of antibody- positive generalized MG reduces the maintenance dose of prednisolone and is associated with fewer treatment failures,longer remissions,and fewer side effects. |
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